In contrast with mouse thymocytes, mouse ES cells contain increased levels of total genomic H3K4me3 and have larger H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 46 In agreement with this, world decreases in H3K4me3 ranges occur throughout retinoic acid (RA)-induced differentiation of mouse ES cells forty seven In addition, there are dynamic adjustments in H3K4me3 profiles at particular sets of genes throughout ES cell differentiation.
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